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US 10,369,112 B2Granted
Colonic drug delivery formulation
AssigneeUniversity College London
InventorsAbdul Waseh Basit, Valentine Chidi Ibekwe
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Abstract
A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
Claims27
A method of preparing a delayed release drug formulation, said method comprising:
- forming a core comprising a drug;
- and
- coating the core with a polymer coating preparation comprising a mixture of a first material which is susceptible to attack by colonic bacteria and a second material which is a film forming polymeric material having a pH threshold at about pH 6.5 or above,
- wherein the first material comprises a polysaccharide selected from the group consisting of amylopectin;
- and starch comprising no more than 75% amylose
- wherein a ratio of the first material to the second material in the mixture is from 15:85 to less than 99:1,
- wherein the coating has a thickness as measured by theoretical weight gain of from about 4% to about 35% and
- wherein release of the drug is delayed until the colon of the subject.
5 more elements
Dependencies are inferred from the claim text.