Treatment method and product for uterine fibroids using purified collagenase
AssigneesBioSpecifics Technologies Corp., Duke University
InventorsPhyllis Carolyn Leppert, Thomas L. Wegman
Life of this patent
Estimating the term…
Abstract
The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Claims36
A method for the treatment of uterine fibroids in a patient comprising administering into the uterine fibroid a composition comprising an amount of collagenase from Clostridium histolyticum sufficient to cleave disordered collagen fibrils of types I, III and V in said uterine fibroids, wherein said administering is by injecting or inserting into the fibroid about 0.06 to about 1 mg of said collagenase per 1 cm3 uterine fibroid tissue.
A method for the treatment of uterine fibroids in a patient, comprising administering into the uterine fibroid a composition comprising an amount of collagenase from Clostridium histolyticum sufficient to cleave disordered collagen fibrils of types I, III and V in said uterine fibroids, wherein said amount is 0.25-2.0 mg/mL collagenase from Clostridium histolyticum, and wherein said administering is by injecting or inserting said composition into the uterine fibroid tissue.
Dependencies are inferred from the claim text.