Abuse-proofed dosage form
AssigneeGrüNenthal GmbH
InventorsJohannes Bartholomaeus, Heinrich Kugelmann
Life of this patent
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Abstract
A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
Claims28
A tablet for oral administration with reduced potential for parenteral abuse, said tablet comprising:
- (a) one or more active ingredients having potential for abuse selected from the group consisting of hydrocodone, morphine, oxycodone, tramadol, and pharmaceutically acceptable salts and solvates thereof;
- and
- (b) at least one viscosity-increasing agent in a quantity such that an aqueous extract of a total content of the tablet when comminuted and combined with 10 ml of water at 25° C. forms a gel that can be drawn up into and injected back out of a hypodermic needle having a diameter of 0.9 mm, into a further quantity of water, wherein threads of the gel injected from said needle remain visible to the naked eye in said further quantity of water at 37° C.
A solid dosage form for oral administration with reduced potential for parenteral abuse, said dosage form comprising:
- (a) one or more active ingredients having potential for abuse selected from the group consisting of hydrocodone, morphine, oxycodone, tramadol, and pharmaceutically acceptable salts and solvates thereof;
- and
- (b) one or more viscosity-increasing components, in a total quantity, for all said components combined, that is equal to or greater than 5 mg per dosage form, that quantity being selected such that an aqueous extract of a total content of the dosage form, when comminuted and combined with 10 ml of water at 25° C., forms a gel that is capable of being drawn into and then expelled from a hypodermic needle having a diameter of 0.9 mm, wherein threads of said gel, formed upon exit from said needle into a further quantity of water at 37° C., remain visible to the naked eye.
A tablet for oral administration with reduced potential for parenteral abuse, said tablet comprising:
- (a) one or more active ingredients with potential for abuse selected from the group consisting of hydrocodone, morphine, oxycodone, tramadol and pharmaceutically acceptable salts and/or solvates thereof;
- and
- (b) one or more viscosity-increasing agents;
- wherein the tablet when its total content is comminuted and combined with 10 ml of water at 25° C. forms an injectable gel that can be drawn up into and injected back out of a syringe having a diameter of 0.9 mm, but wherein the injectable gel cannot be safely injected from said syringe into a blood vessel of an abuser because the presence of the injectable gel in the abuser's blood vessels would obstruct one or more of said abuser's blood vessels.
Dependencies are inferred from the claim text.