Neuroprotective liposome compositions and methods for treatment of stroke
AssigneeBoard of Regents, The University of Texas System
InventorsShao-Ling Huang, Melvin E. Klegerman, Yong-Jian Geng, Hyunggun Kim, David D. McPherson
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Abstract
Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.
Claims25
A method of treating stroke in a subject who has been determined to have hemorrhagic stroke as a result of an intracranial aneurysm or subarachnoid hemorrhage comprising administering an effective amount of a composition comprising xenon-loaded echogenic liposomes to the subject, wherein the composition reduces infarct size in the treated subject.
Dependencies are inferred from the claim text.