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AssigneeThe Trustees of the University of Pennsylvania
InventorsHyun Koo, Lizeng Gao, David Cormode, Pratap Naha
Estimating the term…
The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.
A method of treating an oral disease comprising:
A method of treating an oral disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
A method of treating a biofilm-associated disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
A method of treating an oral disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the concentration of the iron nanoparticles within the composition is from about 0.01 to about 10.0 mg/ml.
A method for the elimination and/or treatment of an oral disease comprising:
A method of treating a biofilm-associated disease comprising:
Dependencies are inferred from the claim text.