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US 10,368,791 B2Granted
Devices and associated methods for monitoring of neuromodulation using biomarkers
AssigneeMedtronic Adrian Luxembourg S.a.r.l.
InventorsAyala Hezi-Yamit, Rudy Beasley, Susan Thornton Edwards, Lori Garcia, Michele Lee Silver, Christopher W. Storment, Carol M. Sullivan, Joseph A. Traina, Stefan Stoyanov Tunev
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Abstract
Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.
Claims22
A catheter for determining biomarker activity in a human patient during a neuromodulation procedure, the catheter comprising:
- an elongated shaft including a distal portion configured for transluminal delivery to a target blood vessel of a human patient;
- an energy delivery element at the distal portion of the shaft and configured to, during an ablation procedure, deliver energy sufficient to at least partially ablate target neural fibers adjacent to the target blood vessel of the patient;
- a capture compartment configured to intravascularly obtain a volume of at least one type of biomarker from the patient, wherein the at least one type of biomarker is secreted as a result of the ablation procedure;
- and
- an analyzer operably coupled to the shaft, wherein the analyzer is configured to receive at least a portion of the volume and detect a concentration of one or more types of biomarkers from the portion of the volume, and wherein the concentration corresponds, at least in part, to a degree of ablation of the target neural fibers.
2 more elements
Dependencies are inferred from the claim text.