System and methods for wireless drug delivery on command

An integrated miniaturized implantable device comprising:

• a substrate for monolithic integration comprising a plurality of metal layers separated via a plurality of insulating layers;
• a monolithically integrated electronic system comprising an energy storage element adapted to be charged through a wireless communication link;
• a monolithically integrated coil on a first surface of the substrate, the monolithically integrated coil configured to provide the wireless communication link;
• and
• a hermetic package comprising at least one chamber that contains a liquid payload, the hermetic package is in its entirety fixated on the first surface of the substrate, a portion of the hermetic package being positioned on the monolithically integrated coil,
• wherein during operation of the implantable device, the electronic system is configured to:
• communicate with an external device over the wireless communication link provided by the monolithically integrated coil,
• extract power for the miniaturized implantable device from the wireless communication link,
• charge the energy storage element based on the extracted power, and
• energize an actuator via the energy storage element to rupture a seal of the hermetic package.