Electro-medical system for neuro-muscular paralysis assessment

An apparatus for quantitatively determining a person's neuromuscular blockade (NMB) level in real-time using a sensor attached to the person, the apparatus comprising:

• a stimulus electrode, the stimulus electrode configured to deliver a stimulus current to the person for a time duration that is longer than the baseline chronaxie;
• the sensor receiving a signal including a measurement of the muscular response to the stimulus current, the sensor being coupled to the stimulus electrode;
• and
• a paralysis assessment system including a micro-computer configured to receive the signal and determine the person's NMB level based on the signal, wherein the paralysis assessment system is configured to:
• receive a first input signal from the sensor, wherein the first input signal includes a measurement of a first muscular response, the first muscular response resulting from a first stimulus current (I1) delivered to the person before administration of NMB agents to the person;
• establish a baseline chronaxie (PC1) based on the first input signal;
• deliver one or more second stimulus currents (Icurrent) to the person after the administration of NMB agents to the person;
• receive a second input signal from the sensor, wherein the second input signal includes a measurement of one or more second muscular responses resulting from the one or more second stimulus currents (Icurrent);
• determine a temporal chronaxie (PCcurrent) based on the second input signal;
• and
• determine the person's NMB level based on at least one of a chronaxie ratio of temporal chronaxie (PCcurrent) to baseline chronaxie (PC1) and a current ratio of one of the second stimulus currents (Icurrent) to the first stimulus current (I1);
• determine an amount of NMB agents or an amount of NMB reversing agents to administer to the person, based on at least the person's determined NMB level;
• and,
• a drug delivery system, connected to the paralysis assessment system, for administering the determined amounts of NMB agents or NMB reversing agents to the person.

A non-transitory computer-readable medium storing instructions that, when executed;

• causes a computer to perform a method for quantitatively determining a person's neuro-muscular blockade (NMB) level in real-time using at least one sensor attached to the person, the method comprising:
• generating an electrical stimulus that is applied to the sensor;
• receiving a first input signal from the sensor, wherein the first input signal includes a measurement of a first muscular response made by the sensor, the first muscular response resulting from a baseline stimulus current delivered to the person before administration of NMB agents to the person;
• establishing, via a micro-computer that is connected to the sensor, a baseline chronaxie (PC1) based on the first input signal;
• delivering, via the sensor, one or more stimulus currents (Icurrent) to the person for one or more time durations that are longer than the baseline chronaxie (PC1), after the administration of NMB agents to the person;
• receiving a second input signal from the sensor, wherein the second input signal includes a measurement made by the sensor of one or more muscular responses resulting from the one or more stimulus currents (Icurrent);
• determining, via the micro-computer, a temporal chronaxie (PCcurrent) based on the second input signal;
• and
• determining, via the micro-computer, the person's NMB level based on at least one of a chronaxie ratio of temporal chronaxie (PCcurrent) to baseline chronaxie (PC1) and current ratio of one of the second stimulus currents (Icurrent) to the first stimulus current (I1),
• determining, via the micro-computer, an amount of NMB agents or an amount of NMB reversing agents to administer to the person, based on at least the person's determined NMB level, and
• administering, via a drug delivery system connected to the micro-computer, the determined amounts of NMB agents or NMB reversing agents to the person.