Systems and methods for optimizing insulin dosage

A testing method suitable for a diabetic person to optimize an administered insulin dosage comprising:

• providing a structured collection procedure from a server of a health care provider to a collection device configured to guide the diabetic person through the structured collection procedure and optimize the administered insulin dosage, wherein the collection device comprises a meter configured to measure one or more selected biomarkers, a processor disposed inside the meter and coupled to a memory, wherein the memory stores the structured collection procedure provided from the server, and software having instructions that when executed by the processor causes the processor to instruct the diabetic person to collect one or more sampling sets of biomarker data in accordance with the structured collection procedure, wherein the server is a central repository for a plurality of the structured collection procedures;
• collecting one or more sampling sets of biomarker data by the collection device, wherein each of the one or more sampling sets comprises a plurality of sampling instances recorded over a collection period and each sampling instance of the plurality of sampling instances comprises an acceptable biomarker reading recorded upon compliance with one or more acceptance criterion based on at least one of a schedule-based action or a patient-based action and that is applied to the one or more sampling sets of biomarker data, wherein the one or more acceptance criterion require collection of the acceptable biomarker reading by the diabetic patient at a time required by the collection device;
• wherein after each collection of the one or more sampling sets of biomarker data, said processor performs the processes of:
• calculating a biomarker sampling parameter from the one or more sampling sets of biomarker data and as a function of only these biomarker data that are in compliance with the one or more acceptance criterion;
• comparing the biomarker sampling parameter to a target biomarker range;
• calculating an insulin adjustment parameter associated with the biomarker sampling parameter in response to the biomarker sampling parameter falling outside the target biomarker range;
• adjusting an insulin dosage by an amount of the insulin adjustment parameter in response to the biomarker sampling parameter falling outside the target biomarker range and in response to the insulin dosage not exceeding maximum dosage;
• and exiting the testing method in response to the adjusted insulin dosage being optimized as an optimized insulin dosage such that the optimized insulin dosage is administered as the administered insulin dosage, otherwise repeating with a next sampling set of the one or more sampling sets of biomarker data, the optimized insulin dosage being achieved when the one or more biomarker sampling parameters fall within the target biomarker range.