Methods and systems for combined morphological and angiographic analyses of retinal features

A method to detect disease in the eye based on images obtained from the foveal avascular zone (FAZ) of the eye, said method comprising:

• (a) collecting a plurality of images of the eye, including the FAZ of the eye, using an optical coherence tomography (OCT) system, said OCT system collecting both (i) structural morphological or anatomical images and (ii) functional angiographic blood flow images, said functional images being obtained by collecting data at the same location in the eye at different times to permit analysis of motion;
• (b) using an electronic processor, determining a size parameter of the FAZ based on an analysis of the structural images, said size parameter being either the diameter or the area of the FAZ;
• (c) using an electronic processor, determining a size parameter of the FAZ based on an analysis of the functional images, said size parameter being the same as in step (b);
• (d) using an electronic processor, comparing the size parameters determined in steps (b) and (c) to evaluate the state of disease in the eye;
• and
• (e) displaying the results of the comparison on a display or storing the results in an electronic processor for further analysis.