Compounds for the inhibition of indoleamine-2,3-dioxygenase

A compound of formula II,

• or a pharmaceutically acceptable salt thereof, wherein:
• R1a is —R, halogen, -haloalkyl, -hydroxyalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• R1b is —R, halogen, -haloalkyl, -hydroxyalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• or
• R1a and R1b, together with the atom to which each is attached, may form a fused or spiro ring selected from C5-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of which is optionally substituted;
• Ring A is cyclohexyl, piperidinyl, tetrahydropyranyl or phenyl;
• each R2 is independently R, halogen, —OR, —C(O)R, or —C(O)N(R)2,
• X1, X2, or X3, are each, independently, selected from carbon, nitrogen, oxygen, or sulfur provided that at least one of X1, X2 or X3 is not carbon;
• each R3 is independently —R, halogen, -haloalkyl, -hydroxyalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• Z is selected from nitrogen, oxygen, or sulfur;
• each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of which is optionally substituted;
• or
• two R groups on the same atom are taken together with the atom to which they are attached to form a C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of which is optionally substituted;
• m is 1 or 2;
• n is 0, 1, 2, or 3;
• and
• p is 0, 1 or 2.