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US 10,319,577 B2Granted
Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry
AssigneeMicromass UK Limited
InventorsRobert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
Life of this patent
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Abstract
A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a desired charge state are onwardly transmitted to the collision cell.
Claims16
A mass spectrometer comprising:
- a first mass to charge ratio filter or mass to charge ratio mass analyser arranged and adapted in a first mode of operation to transmit ions having a mass to charge ratio within a first range;
- an ion mobility spectrometer or separator adapted in a mode of operation to separate ions according to ion mobility such that ions having substantially the same mass to charge ratio within the first range will exit the ion mobility spectrometer or separator at substantially different times;
- and
- attenuation means for attenuating ions in a mode of operation;
- wherein said attenuation means is configured such that it is not mass-selective and such that it either substantially allows all ions to be onwardly transmitted, or substantially attenuates all ions by preventing all ions from being transmitted;
- wherein said attenuation means comprises at least one of:
- an ion gate or ion barrier arranged downstream of said ion mobility spectrometer or separator;
- means for removing, attenuating or reducing the amplitude of an AC or RF voltage or potential which is applied to at least a portion of said ion mobility spectrometer or separator;
- and
- means for removing, attenuating or reducing the amplitude of an AC or RF voltage or potential which is applied to at least a portion of an ion guide or other ion optical device arranged downstream of said ion mobility spectrometer or separator;
- the mass spectrometer further comprising a control device configured to control the operation of said attenuation means;
- wherein said control device is configured to control the operation of said attenuation means so that said attenuation means operates to transmit substantially all ions during a first time period or first time window, and said attenuation means operates to attenuate substantially all ions during a second time period or second time window, wherein said second time period or second time window is different from said first time period or first time window, wherein said second time period or second time window is selected such that operation of the attenuation means to attenuate substantially all ions during said second time period or second time window causes ions having mass to charge ratios within said first range but having one or more undesired first charge states to be attenuated.
9 more elements
A method of mass spectrometry using a mass spectrometer having an ion mobility spectrometer or separator, the method comprising:
- transmitting ions having mass to charge ratios within a first range through a first mass to charge ratio filter or mass to charge ratio mass analyser;
- separating ions according to ion mobility using the mobility spectrometer or separator, such that such that ions having substantially the same mass to charge ratio within the first range will exit the ion mobility spectrometer or separator at substantially different times;
- and
- attenuating ions in a mode of operation with attenuation means, wherein said attenuation means is configured such that it is not mass-selective and such that it either substantially allows all ions to be onwardly transmitted, or substantially attenuates all ions by preventing all ions from being transmitted, wherein said attenuation means comprises at least one of:
- an ion gate or ion barrier arranged downstream of said ion mobility spectrometer or separator;
- means for removing, attenuating or reducing the amplitude of an AC or RF voltage or potential which is applied to at least a portion of said ion mobility spectrometer or separator;
- and
- means for removing, attenuating or reducing the amplitude of an AC or RF voltage or potential which is applied to at least a portion of an ion guide or other ion optical device arranged downstream of said ion mobility spectrometer or separator wherein attenuating ions in a mode of operation with attenuation means comprises controlling the operation of said attenuation means so that said attenuation transmits substantially all ions during a first time period or first time window, and said attenuation means attenuates substantially all ions during a second time period or second time window, wherein said second time period or second time window is different from said first time period or first time window, wherein said second time period or second time window is selected such that operation of the attenuation means to attenuate substantially all ions during said second time period or second time window causes ions having mass to charge ratios within said first range but having one or more undesired first charge states to be attenuated.
5 more elements
Dependencies are inferred from the claim text.