Methods and systems for assessing healing of tissue

A method for use in medical imaging for assessing tissue of a subject, the method comprising:

• at a computer system including one or more processors and memory,
• receiving a time series of signal intensity data capturing transit of an imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region;
• determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein a heterogeneous pattern in the coefficient-derived image map is indicative of actual or suspected changes in blood flow and perfusion in the tissue.

A method for visualizing transit of an imaging agent through tissue of a subject, the method comprising:

• at a computer system including one or more processors and memory,
• receiving a time series of signal intensity data capturing the transit of the imaging agent through the tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region;
• determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein a heterogeneous pattern in the coefficient-derived image map is indicative of actual or suspected changes in blood flow and perfusion in the tissue.

A system for allowing assessment of tissue of a subject, the system comprising:

• one or more processors;
• and
• memory having instructions stored thereon, the instructions, when executed by the one or more processors, cause the system to:
• receive a time series of signal intensity data capturing transit of an imaging agent through tissue over a period of time, wherein the time series of signal intensity data define a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to that calculation region;
• determine, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• convert the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein a heterogeneous pattern in the coefficient-derived image map is indicative of an actual or suspected wound.

A system for allowing assessment of tissue of a subject, the system comprising:

• one or more processors;
• and
• memory having instructions stored thereon, the instructions, when executed by the one or more processors, cause the system to:
• receive a time series of signal intensity data capturing transit of an imaging agent through tissue over a period of time, wherein the time series of signal intensity data define a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to that calculation region;
• determine, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• convert the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein the assessing of tissue of the subject is based at least in part on the coefficient-derived image map;
• and
• wherein the assessing of tissue of the subject comprises assessing a wound in the tissue, a peri-wound in the tissue, or a combination thereof.

A kit comprising:

• a system for allowing assessment of tissue of a subject, the system comprising:
• one or more processors;
• and
• memory having instructions stored thereon, the instructions, when executed by the one or more processors, cause the system to:
• receive a time series of signal intensity data capturing transit of an imaging agent through tissue over a period of time, wherein the time series of signal intensity data define a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to that calculation region;
• determine, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• convert the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• and
• an imaging agent, wherein the imaging agent comprises indocyanine green, fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, ophthaldehyde, fluorescamine, rose Bengal, trypan blue, fluoro-gold, green fluorescence protein, a flavin, methylene blue, porphysomes, cyanine dye, IRDDye800CW, CLR 1502 combined with a targeting ligand, OTL38 combined with a targeting ligand, or a combination thereof.

A method for use in medical imaging for assessing tissue of a subject, the method comprising:

• administering an imaging agent to the subject;
• at a computer system including one or more processors and memory,
• receiving a time series of signal intensity data capturing transit of the imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region;
• determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein a heterogeneous pattern in the coefficient-derived image map is indicative of actual or suspected changes in blood flow and perfusion in the tissue.

A method for visualizing transit of an imaging agent through tissue of a subject, the method comprising:

• administering the imaging agent to the subject;
• at a computer system including one or more processors and memory,
• receiving a time series of signal intensity data capturing the transit of the imaging agent through the tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region;
• determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region;
• and
• converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map;
• wherein a heterogeneous pattern in the coefficient-derived image map is indicative of actual or suspected changes in blood flow and perfusion in the tissue.