Chromatography systems and methods using them
AssigneePerkinElmer Health Sciences, Inc.
InventorAndrew Tipler
Life of this patent
Estimating the term…
Abstract
Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
Claims16
A system for modulating flow of a fluid in a chromatography system, the system comprising:
- a microfluidic device fluidically coupled to a switching valve, in which the microfluidic device comprises a first charging chamber and a second charging chamber;
- and
- a detector fluidically coupled to a first outlet of the microfluidic device,
- wherein the switching valve is configured to actuate between a first position and a second position, wherein the first position is configured to permit fluid flow from a modulating gas source to the first charging chamber of the microfluidic device to provide column effluent from the first charging chamber to the detector fluidically coupled to the microfluidic device, and wherein the second position is configured to permit fluid flow from the modulating gas source to the second charging chamber of the microfluidic device to provide column effluent from the second charging chamber to the detector fluidically coupled to the microfluidic device.
Dependencies are inferred from the claim text.