Compositions with improved intravitreal half-life and uses thereof
AssigneeVitrisa Therapeutics, Inc.
InventorsCarl Erickson, Christopher P. Rusconi, Kevin G. McLure, Renta Hutabarat
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for the treatment of retinal diseases. The compositions and methods include a therapeutic agent conjugated to a vitreous component binding moiety. The vitreous component binding moiety may be an aptamer or a small molecule that binds to a structural component of the vitreous humor (e.g., hyaluronic acid, collagen or vitronectin).
Claims28
A composition comprising a therapeutic aptamer conjugated to a vitreous component binding moiety, wherein said vitreous component binding moiety comprises an aptamer that selectively binds to hyaluronan.
Dependencies are inferred from the claim text.