Compositions and methods for inhibiting gene expression of factor XII

A method for the treatment of diseases or conditions associated with angioedema, including hereditary angioedema and venous thromboembolism, in a human subject in need thereof, the method comprising:

• administering to the subject a therapeutically effective amount of a composition comprising an RNA interference (RNAi) trigger capable of inhibiting the expression of an F12 gene, wherein the RNAi trigger comprises a sense strand and an antisense strand, wherein said antisense strand comprises nucleotides 2 to 19 (5′ to 3′) of SEQ ID NO:
• 1417 (GGUCUUUCACUUUCUUGG) and all of the nucleotides of the antisense strand are modified nucleotides, and wherein the sense strand is at least substantially complementary to the antisense strand and all of the nucleotides of the sense strand are modified nucleotides.