Use of an miRNA to reduce proliferation of a cancer cell
AssigneeBoard of Supervisors of Louisiana State University
InventorsFrancesca Peruzzi, Duane Jeansonne
Life of this patent
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Abstract
A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective amount of a pharmaceutically acceptable composition comprising a microRNA (miRNA) having a nucleotide sequence having at least 80% sequence similarity to the nucleotide sequence of miR-3189-3p derived from the miR-3189 mitron of the Growth Differentiation Factor 15 (GDF15) gene. The methods and compositions are advantageous for inhibiting proliferation and migration of, but not limited to, glioblastoma cells, melanoma cells, and breast cancer cells.
Claims11
A method for decreasing at least one of the proliferation and the migration of a glial tumor cell, comprising contacting the cancer cell with a pharmaceutically acceptable composition comprising a microRNA (miRNA) having the nucleotide sequence SEQ ID NO:
- 2, thereby decreasing at least one of the proliferation and migration of the cancer cell as compared to a control.
A method for treating a cancer, wherein the cancer is a glial tumor, the method comprising administering to an animal or human subject in need thereof an effective amount of a pharmaceutically acceptable composition consisting essentially of a microRNA (miRNA) having the nucleotide sequence SEQ ID NO:
- 2, thereby decreasing at least one of the proliferation and migration of the cancer cell as compared to a control.
Dependencies are inferred from the claim text.