miR-96-5p inhibitor and a screening method for the inhibitor
AssigneeTeikyo University
InventorsToshio Nakaki, Chisato Kinoshita
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Abstract
The present invention provides novel medical means to facilitate glutathione (GSH) synthesis in the brain. These means are miR-96-5p inhibitor increasing GSH expression in the brain and a pharmaceutical composition comprising the miR-96-5p inhibitor and having a preventive and/or therapeutic performance to a disease caused by decrease of GSH amount or depression of GSH activity.
Claims5
A method for increasing an expression of glutathione (GSH) in the brain of a subject by administering a miRNA-96-5p inhibitor into the brain of the subject, wherein the miRNA-96-5p inhibitor is an oligonucleotide at least partially complementary to the nucleotide sequence of SEQ ID NO:1.
A method for treating a neurodegenerative disease caused by decrease of glutathione (GSH) amount or depression of GSH activity, which comprises administrating a miRNA-96-5p inhibitor into the brain of a subject, wherein the miRNA-96-5p inhibitor is an oligonucleotide at least partially complementary to the nucleotide sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.