Methods for diagnosing and treating learning or mental disorders
AssigneeSt. Jude Children's Research Hospital
InventorsStanislav S. Zakharenko, Laurie R. Earls
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Abstract
The present invention embraces methods for the diagnosis and treatment of learning or mental disorders such as schizophrenia using miR-25, miR-98, or miR-185.
Claims4
A method for improving hippocampal synaptic plasticity comprising administering to a subject exhibiting an age-dependent alteration in synaptic plasticity an effective amount of microRNA (miR)-98 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby improving the subject's hippocampal synaptic plasticity.
A method for treating a mental disorder comprising administering to a subject having a 22q11 deletion syndrome, schizophrenia, or autism spectrum disorder an effective amount of microRNA (miR) -98 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby treating the subject's mental disorder.
A method for improving hippocampal synaptic plasticity comprising administering to a subject exhibiting an age-dependent alteration in synaptic plasticity an effective amount of microRNA (miR)-25 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby improving the subject's hippocampal synaptic plasticity.
A method for treating a mental disorder comprising administering to a subject having 22q11 deletion syndrome, schizophrenia, or autism spectrum disorder an effective amount of microRNA (miR)-25 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby treating the subject's mental disorder.
Dependencies are inferred from the claim text.