Back to results
US 10,308,930 B2Granted
Methods to accelerate antibody diversification
AssigneeAlbert Einstein College of Medicine
InventorsXiaohua Wang, Matthew Scharff
Life of this patent
Estimating the term…
Abstract
Methods for increasing somatic hypermutation of antibodies, especially in vitro expression of an isolated retroviral protein in an isolated mammalian immunoglobulin-producing cell, are provided.
Claims18
A method of increasing somatic hypermutation of an immunoglobulin loci comprising effecting expression of a Tat protein in (i) an isolated mammalian immunoglobulin-producing cell, or (ii) an isolated immunoglobulin-producing cell of a cell line derived from a mammal, in an amount effective to increase somatic hypermutation of an immunoglobulin loci.
Dependencies are inferred from the claim text.