Multivalent and multispecific DR5-binding fusion proteins
AssigneeInhibrx, Inc.
InventorsJohn C. Timmer, Kyle S. Jones, Amir S. Razai, Abrahim Hussain, Katelyn M. Willis, Quinn Deveraux, Brendan P. Eckelman
Life of this patent
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Abstract
The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
Claims24
An isolated polypeptide that binds death receptor 5 (DR5) and comprises a plurality of DR5 binding domains (DR5BDs), wherein each DR5BD is a VHH comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 128, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 131, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 130, and wherein adjacent DR5BDs are operably linked by an amino acid linker.
An isolated polypeptide that binds death receptor 5 (DR5), wherein the polypeptide is a homodimer of the amino acid sequence of SEQ ID NO:
- 113 fused to an Fc region polypeptide of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.