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US 10,308,712 B2Granted
Antibodies that bind human cannabinoid 1 (CB1) receptor
AssigneeBird Rock Bio, Inc.
InventorsAnke Kretz-Rommel, Lei Shi, Roger Ferrini, Teddy Yang, Fei Xu, Brian Campion
Life of this patent
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Abstract
The present invention relates to novel antibodies and fragments thereof that binds cannabinoid 1 (CB1) receptor. The antibodies and fragments thereof as disclosed herein include humanized antibodies that bind CB1 receptor. The invention also includes uses of the antibodies for treating a disease or disorder responsive to antagonism or agonism of the CB1 receptor.
Claims9
An isolated antibody or antigen binding fragment thereof that binds to cannabinoid receptor 1 (CB1), wherein the antibody or antigen binding fragment comprises:
- a heavy chain comprising a CDR1 amino acid sequence of SEQ ID NO:
- 352, a CDR2 amino acid sequence of SEQ ID NO:
- 353, and a CDR3 amino acid sequence of SEQ ID NO:
- 354;
- and
- a light chain comprising a CDR1 amino acid sequence of SEQ ID NO:
- 355, a CDR2 amino acid sequence of SEQ ID NO:
- 356, and a CDR3 amino acid sequence of SEQ ID NO:
- 357.
6 more elements
Dependencies are inferred from the claim text.