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US 10,308,711 B2Granted
Heavy chain only antibodies to PDGF
AssigneeAllergan, Inc.
InventorsYanbin Liang, Daniel W. Gil
Life of this patent
Estimating the term…
Abstract
Disclosed herein are monospecific HCAb antibodies with antigen-binding specificity to PDGF and bispecific antibodies with antigen-binding specificities to PDGF-2 and VEGF or to PDGF and ANG-2.
Claims7
A heavy-chain only antibody (HCAb) comprising homodimeric variable heavy chain (VH) regions where each VH region comprises:
- a CDR1 having the amino acid sequence of SEQ ID NO:23;
- a CDR2 having the amino acid sequence of SEQ ID NO:24;
- and
- a CDR3 having the amino acid sequence of SEQ ID NO:25;
- wherein the HCAb retains its specificity for PDGF-BB.
2 more elements
Dependencies are inferred from the claim text.