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US 10,308,710 B2Granted
Humanized anti-Tau(pS422) antibodies and methods of use
AssigneeHoffmann-La Roche Inc.
InventorsFiona Grueninger, Guy Georges, Olaf Mundigl, Michael Schraeml, Bernd Bohrmann, Ulrich Goepfert, Joerg Benz, Hubert Kettenberger
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Abstract
The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
Claims6
A humanized antibody that specifically binds to human Tau(pS422), wherein the antibody comprises
- in the light chain:
- a HVR-L1 comprising SEQ ID NO:
- 12,
- a HVR-L2 comprising SEQ ID NO:
- 5, and
- a HVR-L3 comprising SEQ ID NO:
- 6,
- and
- in the heavy chain:
- a HVR-H1 comprising SEQ ID NO:
- 8,
- a HVR-H2 comprising SEQ ID NO:
- 9 or 18, and
- a HVR-H3 comprising SEQ ID NO:
- 10.
12 more elements
Dependencies are inferred from the claim text.