Modified glucagon molecules
AssigneePurdue Research Foundation
InventorsElizabeth M. Murphy Topp, Hamed Tabatabaei Ghomi, Markus Lill, Shenbaga Moorthy Balakrishnan
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Abstract
The invention generally relates to modified glucagon molecules. In certain embodiments, the invention provides a glucagon molecule that includes one or more modified amino acids, e.g., phosphorylation and/or sulfation, to result in the glucagon molecule being soluble at a substantially neutral pH and resistant to fibrillation.
Claims8
A glucagon molecule comprising one or more phosphorylated amino acids.
A glucagon prodrug comprising one or more modified amino acids such that the glucagon prodrug is soluble at a substantially neutral pH, wherein the one or more modified amino acids are modified with a functional group that imparts a charge to the one or more modified amino acids and the functional group is cleaved upon administration of the prodrug, and wherein the one or more modified amino acids are one or more amino acids that have been modified with a phosphate group and the one or more amino acids that have been modified with a phosphate group are selected from the group consisting of Thr5, Ser8, and combinations thereof.
Dependencies are inferred from the claim text.