Therapeutic targeting of SET1B/compass pathway for treating cancers
AssigneeNorthwestern University
InventorsAli Shilatifard, Lu Wang
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Abstract
Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a therapeutic amount of an inhibitor of the Set1B/COMPASS pathway and/or an agonist for a target that is negatively regulated by the Set1B/COMPASS pathway.
Claims2
A method for inhibiting tumor growth of a cancer characterized by expression of Set1B/COMPASS in a subject in need thereof, the method comprising administering to the subject a therapeutic amount of a compound having a formula:
- wherein the cancer is triple negative breast cancer (TNBC).
A method for inhibiting tumor growth of triple negative breast cancer (TNBC) in a subject in need thereof, the method comprising administering to the subject a therapeutic amount of a compound having a formula:
Dependencies are inferred from the claim text.