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US 10,308,697 B2Granted
Fusion proteins for treating cancer and related methods
AssigneePresident and Fellows of Harvard College
InventorsJeffrey Charles Way, Avram Lev Robinson-Mosher
Life of this patent
Estimating the term…
Abstract
Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g., EGFRvIII-expressing cells that also express interferon receptors) and that induce anti-proliferative effects, and related compositions and methods for the treatment of cancer.
Claims16
A fusion protein comprising
- a Type 1 interferon protein domain comprising the sequence of SEQ ID NO:
- 18 or a sequence with one or two mutations relative to SEQ ID NO:18, the mutations selected from the group consisting of:
- L30A, R145A, M149A, E59A, H58A, and R150A;
- an antibody variable region element comprising a heavy chain variable region comprising the amino acid sequence provided by SEQ ID NO:
- 15 and a light chain variable region comprising the amino acid sequence provided by SEQ ID NO:
- 16, wherein the antibody variable region element binds to EGFRvIII;
- and
- a linker that connects the protein domain and the antibody variable region element.
5 more elements
An isolated fusion protein comprising the amino acid sequence of SEQ ID NO:
- 5 [MR1-1 IFNα2-lb H58A R150A].
Dependencies are inferred from the claim text.