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US 10,308,682 B2Granted
Inhibition of tumor growth with aggregates of small molecules
AssigneeBrandeis University
InventorsBing Xu, Yi Kuang
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Abstract
Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. This unprecedented mechanism of “self-assembly to interfere with self-organization” allows inhibition of the growth of cancer cells.
Claims18
A method of treating cancer, comprising the step of:
- administering to a subject in need thereof a plurality of hydrophobic, self-assembling monomers of Formula (I):
- wherein independently for each occurrence:
- is naphthyl;
- R is H or alkyl;
- R1 is substituted or unsubstituted aralkyl or heteroaralkyl;
- R2 is H, alkyl, —OR, or —NR2;
- and
- n is 2, 3, 4, 5, or 6;
- wherein R1 is an unsubstituted aralkyl for at least one of said R1 groups and R1 is a substituted aralkyl or substituted heteroarylalkyl for at least one of said R1 groups;
- and
- wherein the cancer is selected from the group consisting of cervical carcinoma, hepatocarcinoma, glioblastoma, breast carcinoma, pancreatic carcinoma, and uterine sarcoma.
8 more elements
A method of treating cancer, comprising the step of:
- administering to a subject in need thereof a plurality of hydrophobic, self-assembling monomers, wherein the hydrophobic, self-assembling monomer is
- wherein the cancer is selected from the group consisting of cervical carcinoma, hepatocarcinoma, glioblastoma, breast carcinoma, pancreatic carcinoma, and uterine carcinoma.
Dependencies are inferred from the claim text.