Tricyclic benzoxaborole compounds and uses thereof
AssigneesGlaxoSmithKline Intellectual Property (No. 2) Limited, Anacor Pharmaceuticals, Inc.
InventorsMichael Richard Kevin Alley, Vincent Hernandez, Jacob J. Plattner, Xianfeng Li, David Barros-Aguirre, Ilaria Giordano
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Abstract
Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
Claims22
A compound having a structure as shown in Formula II:
- wherein X is selected from chloro or bromo and R1 and R2 are each independently selected from H and —CH3;
- or a pharmaceutically acceptable salt thereof.
A compound having a structure as shown in Formula IIa:
- wherein X is chloro or bromo and R1 and R2 are each independently selected from H and —CH3;
- or a pharmaceutically acceptable salt thereof.
A compound, (S)-(3-chloro-7,8-dihydro-2H-1,6,9-trioxa-9a-borabenzo[cd]azulen-2-yl)methanamine, or a pharmaceutically acceptable salt thereof.
A pharmaceutically acceptable salt, ((S)-(3-chloro-7,8-dihydro-2H-1,6,9-trioxa-9a-borabenzo[cd]azulen-2-yl)methanamine dihydrogensulfate.H2O.
Dependencies are inferred from the claim text.