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US 10,308,656 B2Granted
Small molecule inhibitors of Ku70/80 and uses thereof
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsEric Weterings, Daruka Mahadevan, Josef Vagner
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Abstract
Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
Claims9
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salts, and/or solvates thereof.
Dependencies are inferred from the claim text.