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US 10,308,647 B2Granted
Fused imidazole derivatives as IDO/TDO inhibitors
AssigneeSciFluor Life Sciences, Inc.
InventorsBen C. Askew, Takeru Furuya
Life of this patent
Estimating the term…
Abstract
The present application relates to compounds and methods for the modulation (e.g., inhibition) of the enzyme indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase (IDO/TDO), and methods of treating diseases and disorders in which IDO/TDO plays a role. The present application provides compounds of Formula (I) or (II):
Claims15
A compound of Formula (I)
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- W1 is CR1 or N;
- W2 is CR2 or N;
- W3 is CR3 or N;
- W4 is CR4 or N;
- R1, R2, R3, and R4 are each independently H, OH, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, or C1-C4 haloalkoxy;
- Z1, Z2, and Z3 are each independently a single bond, CHRZ, or CH2CHRZ, wherein one of Z1, Z2, and Z3 is CHRZ, or one of Z1, Z2, and Z3 is CH2CHRZ;
- each RZ is independently H, OH, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, or C1-C4 haloalkoxy;
- Y is H, C1-C4 alkyl, or C1-C4 haloalkyl;
- n is 0, 1, 2, or 3;
- R5 is OH, halogen, C1-C4 alkoxy, or C1-C4 haloalkoxy;
- R6 is H, OH, halogen, C1-C4 alkoxy, or C1-C4 haloalkoxy;
- and
- R7 and R8 are each independently H, halogen, C1-C4 alkyl, or C1-C4 haloalkyl.
11 more elements
Dependencies are inferred from the claim text.