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US 10,308,641 B2Granted
Crystal form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxole-5-yl)cyclopropane formamido)-3-methylpyridine-2-yl)benzoic acid and preparation method thereof
AssigneeCrystal Pharmatech Co., Ltd.
InventorsMinhua Chen, Yanfeng Zhang, Kai Liu, Po Zou, Xiaoyu Zhang
Life of this patent
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Abstract
The present disclosure provides crystalline form A of 3-(6-(1-(2, 2-difluorobenzo [d] [1, 3] dioxo-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and process of preparation thereof. The crystalline form A has low hygroscopicity, good stability, is convenient to store. It has higher solubility than that of prior art and therefore plays an important role in further optimization and development of the drug.
Claims8
A crystalline Form A of compound of formula (I),
- wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 8.8°±0.2°, 9.8°±0.2°, 10.6°±0.2°, 16.2°±0.2°, 18.1°±0.2°, 20.0°±0.2°, 21.2°±0.2°, 22.2°±0.2° 23.5°±0.2°.
Dependencies are inferred from the claim text.