Therapeutic inhibitory compounds

A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula (I):

• wherein,
• Ring A is an optionally substituted bicyclic heteroaryl ring selected from optionally substituted quinolyl, optionally substituted indolyl, optionally substituted indazolyl, optionally substituted benzimidazolyl, optionally substituted isoquinolyl, optionally substituted cinnolinyl, optionally substituted phthalazinyl, optionally substituted quinazolinyl, optionally substituted naphthyridinyl, or optionally substituted benzoisoxazolyl;
• Ring B is an optionally substituted monocyclic heteroaryl ring selected from optionally substituted imidazolyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted pyridazinyl, optionally substituted pyrimidinyl, or optionally substituted pyrazinyl;
• or optionally substituted bicyclic heteroaryl ring selected from optionally substituted quinolinyl, optionally substituted isoquinolinyl, optionally substituted quinazolinyl, optionally substituted indolyl, optionally substituted indazolyl, optionally substituted 1H-pyrrolo[2,3-b]pyridinyl, optionally substituted benzoxazolyl, optionally substituted benzoisoxazolyl, or optionally substituted benzimidazolyl;
• R12 is hydrogen;
• R13 is selected from cyano, halo, hydroxy, azido, amino, nitro, —CO2H, —S(O)—R20, —S—R20, —S(O)2—R20, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O—, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, —CO—R20, —CO2—R20, —CO(NR21)2, —SO2(NR21)2, —C(═NR22)—(NR21)2, or optionally substituted alkynyl;
• R14 is selected from hydrogen, cyano, halo, hydroxy, azido, amino, nitro, —CO2H, —S(O)—R20, —S—R20, —S(O)2—R20, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O—, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, —CO—R20, —CO2—R20, —CO(NR21)2, —SO2(NR21)2, —C(═NR22)—(NR21)2, or optionally substituted alkynyl;
• each R1 or R2 is independently selected from hydrogen, halo, hydroxy, amino, —CO2H, —S(O)—R20, —S—R20, —S(O)2—R20, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O—, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, —CO—R20, —CO2—R20, —CO(NR21)2, —SO2(NR21)2, —C(═NR22)—(NR21)2, or optionally substituted alkynyl;
• or optionally, R1 and R2 are optionally substituted C1-C5 alkyl and join to form a ring;
• or optionally, R1 and R2 together form an oxo;
• each R3 or R4 is independently selected from hydrogen, —CO2H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, —CO—R20, —CO2—R20, —CO(NR21)2, —SO2(NR21)2, —C(═NR22)—(NR21)2, or optionally substituted alkynyl;
• or optionally, R3 and R4 are optionally substituted C1-C5 alkyl and join to form a ring;
• each R20 is selected from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl;
• each R21 is selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl;
• and
• each R22 is selected from hydrogen, —CN, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl.