Heterocyclic compounds and methods for their use

A compound of formula (I):

• wherein Ring G is a 5 to 8 membered ring and
• X is absent or is selected from —(CR6R7)n—, —W—, —(CR6R7)m—W—, —W—(CR6R7)m— and —(CR6R7)p—W—(CR6R7)p—;
• Y is —CR8CR9— wherein R8 and R9 together with the carbon atoms to which they are attached form an optionally substituted aromatic or heteroaromatic ring or ring system;
• Z is absent or is selected from —CR4R5—, —CR6R7CR4R5—, —W—CR4R5—;
• W is selected from —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —NR10—, —C(O)N(R11)—, —N(R11)C(O)—, —C(O)O—, —OC(O)—, —S(O)2N(R11)—, —N(R11)S(O)2—, —N(R11)C(O)N(R11)— and —N(R11)S(O)2N(R11)—;
• R1 is selected from —CO2H, —CH2CO2H, —C(O)C(O)OH, —CH2OH, —C(O)NH2, — CN, —CH2C(O)NH2, —CH2CN, a carboxylic acid bioisostere and —CH2carboxylic acid bioisostere;
• R2 is selected from hydrogen, alkyl, alkenyl, alkynyl, —C1-6alkyleneR12, —C2-6alkenyleneR12 and —C2-6alkynyleneR12;
• R3 is selected from —C(O)CH(aryl)(aryl) and —C(O)N(aryl)(aryl);
• Each R4 and R5 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, —OC(R14)3, —CN, —NO2, —N(R13)2, —CO2R13, — C(O)R13, —C(O)N(R13)2, —S(O)2R13, —S(O)2N(R13)2, —C(R14)3, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl, or R4 and R5 taken together form a carbonyl group;
• R6 and R7 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, —OR13, —SR13, halo, —CN, —NO2, —N(R13)2, —CO2R13, —C(O)R13, —C(O)N(R13)2, —S(O)2R13, S(O)2N(R13)2, —C(R14)3, —OC(R14)3, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl, or R6 and R7 taken together form a carbonyl group;
• R10 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heteroaryl, —C(R14)3, —C(O)R13, —C(O)N(R13)2, —S(O)R13, —S(O)2R13, —S(O)2N(R13)2 and —CO2R13;
• R11 is selected from hydrogen and alkyl;
• R12 is selected from cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl;
• Each R13 is independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl;
• Each R14 is independently selected from hydrogen and halo;
• n is selected from an integer from 1 to 4;
• m is selected from an integer from 1 to 3;
• p is selected from an integer of 1 or 2;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl may be optionally substituted;
• or
• a pharmaceutically acceptable salt thereof.