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US 10,308,620 B2Granted
Muscarinic M1 receptor positive allosteric modulators
AssigneeSuven Life Sciences Limited
InventorsRamakrishna Nirogi, Abdul Rasheed Mohammed, Anil Karbhari Shinde, Shankar Reddy Gagginapally, Venkateswarlu Jasti
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Abstract
The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of preparing such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.
Claims16
A compound of formula (I),
- wherein:
- A1 and A2 are each independently represents CH, CF or N;
- W is O, S, S(O) or S(O)2;
- R1 is
- R2 is
- wherein * represents point of attachment;
- R3 is OH, F, NH2 or H;
- R4 at each occurrence is independently selected from halogen, —O—CH3;
- —S—CH3, —N(CH3)2, —CH3, —CF3, —CHF2, —CH2F, —OH, —CN, phenyl, pyridyl and hydrogen;
- wherein phenyl and pyridyl are optionally substituted with one or more substituents selected from the group consisting of halogen or CH3;
- X is CH2, O or NH;
- and
- a is 0 or 1;
- and b is 1 or 2;
- or an isotopic form, a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.