Back to results
US 10,308,617 B2Granted
Triazole benzamide derivatives and the compositions and methods of treatment regarding the same
AssigneeAn2H Discovery Limited
InventorsJennifer Johnston, Albert W. Garofalo, Paul Ross Fatheree
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.
Claims16
A compound of formula (IA):
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- L3 is a bond;
- M1 and M2 are each independently selected from —NR4C(O)— or —C(O)NR4 —;
- R1 and R2 are each phenyl, substituted with one or more R5a;
- R3 is phenyl, optionally substituted with one or more R5b;
- R4 is each independently H or C1-C3 alkyl;
- R5a is each independently I, Br, Cl, F, C1-C6 alkyl, C1-C3 haloalkyl, —(C1-C6)-O—(C1-C6), C1-C3 alkoxy, C1-C3 haloalkoxy, OH, or COOH;
- R5b is each independently I, Br, Cl, F, CN, CONH2, CONHR6, CONR6R6, COOH, NH2, NHR6, NO2, NR6R6, OH, OR6, —COOR6, OSO3R6, oxo, R6, SH, SO2R6, SO3H, SO3R6, or SR6;
- and
- R6 is each independently alkyl or haloalkyl.
7 more elements
A compound having one of the following structures:
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.