Therapeutic compounds and uses thereof

A compound of formula (I):

• or a salt thereof, wherein:
• R1 is phenyl that is substituted with hydroxy and that is optionally substituted with one or more groups independently selected from the group consisting of halo, cyano, trifluoromethyl, trifluoromethoxy, C1-3alkyl, and C1-3alkoxy;
• R2 is H, C1-6alkyl, or —C(═O)—C1-6alkyl;
• R3 is H or C1-6alkyl;
• R4 is selected from the group consisting of —O—Rb, —N(Rb)2, —S(O)2Rb, —C(O)—N(Rb)2, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein each C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of Rc, oxo, halo, —NO2, —N(Rc)2, —CN, —C(O)—N(Rc)2, —S(O)—N(Rc)2, —S(O)2—N(Rc)2, —O—Rc, —S—Rc, —O—C(O)—Rc, —C(O)—Rc, —C(O)—ORc, —S(O)—Rc, —S(O)2—Rc, —N(Rc)—C(O)—Rc, —N(Rc)—S(O)—Rc, —N(Rc)—C(O)—N(Rc)2, and —N(Rc)—S(O)2—Rc;
• each Rb is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of Rc, oxo, halo, —NO2, —N(Rc)2, —CN, —C(O)—N(Rc)2, —S(O)—N(Rc)2, —S(O)2—N(Rc)2, —O—Rc, —S—Rc, —O—C(O)—Rc, —C(O)—Rc, —C(O)—ORc, —S(O)—Rc, —S(O)2—Rc, —N(Rc)—C(O)—Rc, —N(Rc)—S(O)—Rc, —N(Rc)—C(O)—N(Rc)2, and —N(Rc)—S(O)2—Rc;
• each R is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from Rd;
• or two Rc are taken together with the nitrogen to which they are attached to form a heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3alkyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo and halo;
• each Rd is independently selected from the group consisting of oxo, halo, —NO2, —N(Re)2, —CN, —C(O)—N(Re)2, —S(O)—N(Re)2, —S(O)2—N(Re)2, —O—Re, —S—Re, —O—C(O)—Re, —C(O)—Re, —C(O)—ORe, —S(O)—Re, —S(O)2—Re, —N(Re)—C(O)—Re, —N(Re)—S(O)—Re, —N(Re)—C(O)—N(Re)2, —N(Re)—S(O)2—Re, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of Re, oxo, halo, —NO2, —N(Re)2, —CN, —C(O)—N(Re)2, —S(O)—N(Re)2, —S(O)2—N(Re)2, —O—Re, —S—Re, —O—C(O)—Re, —C(O)—Re, —C(O)—ORe, —S(O)—Re, —S(O)2—Re, —N(Re)—C(O)—Re, —N(Re)—S(O)—Re, —N(Re)—C(O)—N(Re)2, and —N(Re)—S(O)2—Re;
• and
• each Re is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and carbocyclyl(C1-3alkyl)-.

A compound of formula (I):

• or a salt thereof, wherein:
• R1 is 2-hydroxy phenyl that is optionally substituted with one or more groups independently selected from the group consisting of halo;
• R2 is H;
• R3 is H;
• R4 is selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, 3-15 membered heterocyclyl —O—Rb, —N(Rb)2, —S(O)2Rb, and —C(O)—N(Rb)2, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl of R4 is substituted with one or more groups independently selected from the group consisting of C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, 3-15 membered carbocyclyl, 3-15 membered heterocyclyl, oxo, halo, —NO2, —N(Rc)2, —CN, —C(O)—N(Rc)2, —S(O)—N(Rc)2, —S(O)2—N(Rc)2, —O—Rc, —S—Rc, —O—C(O)—Rc, —C(O)—Rc, —C(O)—ORc, —S(O)—Rc, —S(O)2—Rc, —N(Rc)—C(O)—Rc, —N(Rc)—S(O)—Rc, —N(Rc)—C(O)—N(Rc)2, and —N(Rc)—S(O)2—Rc;
• each Rb is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of Rc, oxo, halo, —NO2, —N(Rc)2, —CN, —C(O)—N(Rc)2, —S(O)—N(Rc)2, —S(O)2—N(Rc)2, —O—Rc, —S—Re, —O—C(O)—Rc, —C(O)—Rc, —C(O)—ORc, —S(O)—Rc, —S(O)2—Rc, —N(Rc)—C(O)—Rc, —N(Rc)—S(O)—Rc, —N(Rc)—C(O)—N(Rc)2, and —N(Rc)—S(O)2—Rc;
• each Rc is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from Rd;
• or two Rc are taken together with the nitrogen to which they are attached to form a heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3alkyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo and halo;
• each Rd is independently selected from the group consisting of oxo, halo, —NO2, —N(Re)2, —CN, —C(O)—N(Re)2, —S(O)—N(Re)2, —S(O)2—N(Re)2, —O—Re, —S—Re, —O—C(O)—Re, —C(O)—Re, —C(O)—ORe, —S(O)—Re, —S(O)2—Re, —N(Re)—C(O)—Re, —N(Re)—S(O)—Re, —N(Re)—C(O)—N(Re)2, —N(Re)—S(O)2—Re, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, 3-15 membered carbocyclyl, and 3-15 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of Re, oxo, halo, —NO2, —N(Re)2, —CN, —C(O)—N(Re)2, —S(O)—N(Re)2, —S(O)2—N(Re)2, —O—Re, —S—Re, —O—C(O)—Re, —C(O)—Re, —C(O)—ORe, —S(O)—Re, —S(O)2—Re, —N(Re)—C(O)—Re, —N(Re)—S(O)—Re, —N(Re)—C(O)—N(Re)2, and —N(Re)—S(O)2—Re;
• and
• each Re is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and carbocyclyl(C1-3alkyl)-.