Method for producing 1-(acyloxy)alkyl carbamate derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsTsuyoshi Ueda, Yuzo Abe
Life of this patent
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Abstract
A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, R1 represents C1-C4 alkyl group or a C3-C6 cycloalkyl group, R2 represents a C1-C4 alkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).
Claims14
A compound of formula (I):
- wherein R1 is a C1-C4 alkyl group or a C3-C6 cycloalkyl group,
- R2 is a C1-C4 alkyl group or a hydrogen atom,
- A is a fluorous alkyl group, and
- the fluorous alkyl group is a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms.
A method of producing a compound of formula (I):
- comprising allowing a compound of formula (IV):
- to come into contact with a compound of formula (V):
- wherein R1 is a C1-C4 alkyl group or a C3-C6 cycloalkyl group,
- R2 is a C1-C4 alkyl group or a hydrogen atom,
- A is a fluorous alkyl group, and
- the fluorous alkyl group is a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms.
A method of producing a compound of formula (VI):
- comprising allowing a compound of formula (XI):
- to react with an enzyme in an inert solvent to hydrolyze a compound of formula (VIII):
- and then removing a product obtained by the hydrolysis,
- wherein the enzyme is configured to selectively hydrolyze the compound of formula (VIII).
Dependencies are inferred from the claim text.