Method for producing pyrrole derivative, and intermediate thereof
AssigneeDaiichi Sankyo Company, Limited
InventorsMasashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Abstract
The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.
Claims5
A pyrrole compound represented by the formula (B):
- wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group.
Ethyl (S)-1-(2-hydroxyethyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate represented by the formula (Ia):
Dependencies are inferred from the claim text.