Biosensor for the detection of target components in a sample
AssigneeKoninklijke Philips N.V.
InventorsAlbert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Gwenola Sabatte, Wilhelmina Maria Hardeman
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Abstract
The invention relates to a method and a biosensor system (300) for the detection of target components (TC) in a biological sample. In a preferred embodiment, magnetic purification particles (PP) are added to the sample that can bind interfering components (IC) (if present) which interfere with the detection process. The purification particles (PP) with bound interfering components (IC) may be removed from the sample and transferred through a magneto-capillary valve (MCV1) into a waste chamber (320).
Claims14
A biosensor system for detection of target components in a sample that comprises interfering components which may interfere with the detection of the target components, comprising:
- a purification chamber with an inlet for introduction of the sample;
- purification particles that can bind interfering components of the sample in the purification chamber;
- a detection-particle storage chamber configured to provide magnetic detection particles, the detection-particle storage chamber comprising a first protrusion that points to a first mirror symmetric protrusion of the purification chamber, wherein the magnetic detection particles bind target components of the sample;
- wherein the detection particle storage chamber that is connected to the purification chamber via a magneto-capillary valve through which the detection-particles can controllably be moved;
- and
- a waste chamber that is connected to the purification chamber via a magneto-capillary valve through which the purification particles can controllably be moved, wherein the waste chamber comprises a second protrusion that points toward a second mirror symmetric protrusion of the purification chamber.
Dependencies are inferred from the claim text.