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US 10,307,609 B2Granted
Compositions and methods for controlling pain
AssigneesThe Board of Trustees of the Leland Stanford Junior University, Circuit Therapeutics, Inc.
InventorsShrivats Mohan Iyer, Scott L. Delp, Kathryn L. Montgomery, Karl A. Deisseroth, Christopher Towne
Life of this patent
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Abstract
The present disclosure provides compositions and methods for controlling pain. The present disclosure provides methods for identifying agents that control pain.
Claims20
A method for controlling pain in an individual, the method comprising:
- a) administering, via direct or intrathecal administration, to the individual a recombinant expression vector comprising a nucleotide sequence encoding a hyperpolarizing opsin polypeptide, wherein the opsin polypeptide is expressed in a nociceptor in the individual;
- and
- b) activating the opsin polypeptide with light, thereby controlling the pain in the individual.
Dependencies are inferred from the claim text.