Devices, systems and methods for enhancing intraluminal drug delivery and uptake

A system for enhancing the efficiency of administering therapeutic agents and delivering a therapeutically effective amount of the therapeutic agent to the wall of a biological conduit in a treatment region of interest of a patient, the biological conduit having a diameter, comprising:

• a catheter inserted at least partially within the biological conduit and comprising a lumen;
• an inflatable balloon attached proximate a distal end of the catheter and comprising
• an inflatable portion, and
• an intermediate section in the inflatable portion and comprising a plurality of apertures therethrough;
• a therapeutic agent infusion lumen in fluid communication with the plurality of apertures;
• a therapeutic agent reservoir located outside the patient's body, comprising therapeutic agent therein, the therapeutic agent within the therapeutic agent reservoir in fluid communication with the therapeutic agent infusion lumen;
• a balloon infusion lumen in fluid communication with the inflatable balloon, wherein the balloon infusion lumen and therapeutic agent infusion lumen are not in fluid communication with each other;
• a therapeutic agent pumping mechanism located outside the patient's body and in fluid communication with the therapeutic agent reservoir, the therapeutic agent infusion lumen and the apertures, but not in fluid communication with the balloon infusion lumen;
• and
• a pulse generator located outside the patient's body and in operative communication with the therapeutic agent pumping mechanism and further adapted to generate a range of therapeutically effective frequencies to the therapeutic agent to drive the therapeutic agent through the therapeutic agent infusion lumen and out of the plurality of apertures of the inflatable balloon in response to pulses generated by the therapeutic agent pulse generator that correspond with the generated therapeutically effective frequencies.