Gradient porous scaffolds
AssigneeUniversity of Connecticut
InventorsSyam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini, Deborah L. Dorcemus
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Abstract
The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
Claims11
A gradient porous scaffold, comprising a plurality of biodegradable microspheres that are joined to form a scaffold, wherein the scaffold comprises a continuous porosity gradient along the length of the scaffold, wherein a first end of the scaffold has a porosity of between about 10% to about 40%, and a second end of the scaffold has a porosity of between about 65% to about 75%, wherein the gradient porous scaffold further comprises a hydrogel present throughout the scaffold, wherein an increased amount of the hydrogel is present at the second end compared to the first end.
Dependencies are inferred from the claim text.