Process for preparing hydrogels
AssigneeTeoxane
InventorsFrancois Bourdon, Stephane Meunier
Life of this patent
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Abstract
The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.
Claims19
A process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising:
- a) providing a solution formed from an aqueous medium comprising at least one polysaccharide or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate;
- b) crosslinking the solution from step a) to form a crosslinked gel, and
- c) recovering said crosslinked gel.
An injectable and sterile dermatological composition comprising, in a physiologically acceptable medium, at least one crosslinked gel having at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
A cosmetic or dermatological composition comprising at least one crosslinked gel having at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
A kit comprising:
- packaging containing at least one dose of a crosslinked gel, the crosslinked gel having at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate;
- and
- a device for injection into or through the skin or a skin microperforation device for administration of the one dose of the crosslinked gel.
A method for filling skin volume defects by administering a crosslinked gel having at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
A crosslinked gel for treating gingival deficiencies comprising at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
A crosslinked gel for articular viscosupplementation comprising at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
A crosslinked gel for treating ophthalmic disorders comprising at least one polysaccharide or a salt thereof, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt, the at least one phosphate salt being sodium trimetaphosphate.
Dependencies are inferred from the claim text.