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US 10,307,510 B2Granted
Methods of removing alpha-galactose
AssigneeLifeCell Corporation
InventorsHui Xu, Li Ting Huang, Hua Wan, Rick T. Owens, Nathaniel Bachrach
Life of this patent
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Abstract
Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.
Claims18
A method of preparing a dermal tissue product, comprising:
- selecting at least one collagen-containing tissue matrix contained within a cellular dermal tissue and containing galactose alpha-1,3-galactose moieties;
- and
- contacting the at least one collagen-containing tissue matrix contained within the cellular dermal tissue with alcalase under conditions sufficient to remove galactose alpha-1,3-galactose moieties from the tissue matrix contained within the cellular dermal tissue;
- thereby preparing a dermal tissue product.
1 more element
Dependencies are inferred from the claim text.