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US 10,307,492 B2Granted
Modified MGLUR6 promoter and methods of use
AssigneeWayne State University
InventorsZhuo-Hua Pan, Qi Lu, Tushar H. Ganjawala, JrGang Cheng
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Abstract
The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.
Claims17
An isolated nucleic acid molecule comprising
- a. an mGluR6 enhancer or a variant thereof at least 70% identical to SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- b. an mGluR6 promoter or a variant thereof at least 70% identical to SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, or SEQ ID NO:
- 6;
- c. an intron 4 of the mGluR6 gene or a variant thereof at least 70% identical to SEQ ID NO:
- 7 or SEQ ID NO. 8;
- and
- d. an intron 3 of the mGluR6 gene or a variant thereof at least 70% identical to SEQ ID NO:
- 9 or SEQ ID NO. 10.
10 more elements
Dependencies are inferred from the claim text.