Microvessel endothelial cell surface markers and uses thereof
AssigneesPresident and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
InventorsUlrich H. von Andrian, Aude Thiriot, Omid Farokhzad, Jinjun Shi
Life of this patent
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Abstract
Disclosed herein are microvessel endothelial cell surface markers and methods, compositions, agents, and kits relating to those surface markers.
Claims12
A method of delivering a targeting agent to a microvessel endothelial cell in adipose tissue or skin in a subject, comprising administering to the subject a microvessel endothelial cell targeting agent which binds to a protein encoded by Il6st expressed on the surface of a microvessel endothelial cell in adipose tissue or skin, wherein the microvessel endothelial cell targeting agent is delivered specifically to a microvessel endothelial cell in adipose tissue or skin expressing the protein encoded by Il6st, and causes an effect in the microvessel endothelial cell, or a microvessel, tissue or organ adjacent to the microvessel endothelial cell.
A method of treating a microvessel endothelial cell-associated disorder of adipose tissue or skin in a subject in need thereof, comprising administering to the subject an effective amount of a microvessel endothelial cell targeting agent which binds to a protein encoded by Il6st expressed on the surface of a microvessel endothelial cell in adipose tissue and skin, wherein the microvessel endothelial cell targeting agent is delivered specifically to a microvessel endothelial cell in adipose tissue and skin expressing the protein encoded by Il6st;
- and the microvessel endothelial cell targeting agent is a therapeutic agent for treating the microvessel endothelial cell-associated disorder.
A method of delivering a targeting agent to a microvessel endothelial cell in adipose tissue or skin, comprising administering a microvessel endothelial cell targeting agent which binds to a protein encoded by Il6st expressed on the surface of a microvessel endothelial cell in adipose tissue or skin, wherein the microvessel endothelial cell targeting agent is delivered specifically to a microvessel endothelial cell in adipose tissue or skin expressing the protein encoded by Il6st and causes an effect in the microvessel endothelial cell, or a microvessel, tissue or organ adjacent to the microvessel endothelial cell.
Dependencies are inferred from the claim text.