Nanoparticle complexes of paclitaxel, cetuximab, and albumin
AssigneeMayo Foundation for Medical Education and Research
InventorsSvetomir N. Markovic, Wendy K. Nevala
Life of this patent
Estimating the term…
Abstract
Described are nanoparticle complexes comprising paclitaxel, albumin and anti-EGFR antibodies. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses EGFR.
Claims17
An antibody-albumin nanoparticle complex comprising albumin, a cetuximab antibody, and paclitaxel, wherein the nanoparticle complex has been pre-formed in vitro by mixing an aqueous albumin-paclitaxel nanoparticle with the antibody under conditions to form the nanoparticle complex, such that the nanoparticle complex has EGFR binding specificity, wherein the complex has a diameter of about 0.1 μm to about 1 μm.
The antibody-albumin nanoparticle complex of clam 2, wherein said alkyating agent is a platinum compound.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and antibody-albumin nanoparticle complexes, wherein said antibody-albumin complexes comprise albumin, a cetuximab antibody, and paclitaxel, wherein the nanoparticle complexes have been pre-formed in vitro by mixing an aqueous albumin-paclitaxel nanoparticles with the antibody under conditions to form the nanoparticle complexes, such that the nanoparticle complexes have EGFR binding specificity, wherein the average diameter of at least 90 percent of said complexes is between 0.1 μm and 0.95 μm.
A method of making an antibody-albumin nanoparticle complex, the method comprising mixing in vitro an aqueous albumin-paclitaxel nanoparticle with a cetuximab antibody under conditions to form the nanoparticle complex, wherein the complex has a diameter of about 0.1 μm to about 1 μm.
Dependencies are inferred from the claim text.