US 10,307,481 B2Granted

CD37 immunotherapeutics and uses thereof

AssigneeAptevo Research and Development LLC

InventorsLaura S. Grosmaire, Martha S. Hayden-Ledbetter, Jeffrey A. Ledbetter, Peter A. Thompson, Sandy A. Simon, William Brady

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Abstract

The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.

Claims14

Dependent claims

A humanized or chimeric CD37-specific immunoglobulin binding protein, comprising:

(a) a light chain variable region comprising, from amino terminus to carboxy terminus, a first framework region, a light chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
61, a second framework region, a light chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
64, a third framework region, a light chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
66, and a fourth framework region;
and
(b) a heavy chain variable region comprising, from amino terminus to carboxy terminus, a first framework region, a heavy chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
63, a second framework region, a heavy chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
65, a third framework region, a heavy chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
69, and a fourth framework region;
wherein the binding protein binds human CD37.

7 more elements

A humanized or chimeric CD37-specific immunoglobulin binding protein, comprising:

(a) a light chain variable region comprising, from amino terminus to carboxy terminus, a first framework region, a light chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
61, a second framework region, a light chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
64, a third framework region, a light chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
66, and a fourth framework region;
and
(b) a heavy chain variable region comprising, from amino terminus to carboxy terminus, a first framework region, a heavy chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
63, a second framework region, a heavy chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
65, a third framework region, a heavy chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
67, and a fourth framework region;
wherein the binding protein binds human CD37.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/493,132Filed 25 Jul 2006 · us provisional application
Priority: 25 Jul 2005
Published: US 2007/0059306 A115 Mar 2007
Granted: 4 Jun 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification42 codes

A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…

Family

Application60/702,499Us provisional application · filed 25 Jul 2005
Application60/800,595Us provisional application · filed 16 May 2006
US 2007/0059306 A1Pre-grant publication · published 15 Mar 2007
US 10,307,481 B2This patent

From the US filing history. Foreign family members aren’t listed.

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