Genetically stable live attenuated respiratory syncytial virus vaccine and its production

A recombinant infectious respiratory syncytial virus comprising a large polymerase protein (L), phosphoprotein (P), nucleocapsid protein (N), a M2-1 protein nonstructural protein 1 (NS1), a glycoprotein (G), a fusion protein (F), a matrix protein (M), a M2-2 protein, and a small hydrophobic protein (SH), and a genome or antigenome having:

• a deletion of the codon that encodes the serine at position 1313, or a corresponding position, of the L protein,
• a mutation of amino acid sequence residue 1314, or a corresponding position, of the L protein, wherein the mutation of L protein amino acid sequence residue 1314 is an amino acid substitution of leucine for isoleucine, wherein the leucine is encoded by a codon set forth as CTG;
• and
• a deletion of the NS2 gene.